Expression pattern, prognostic value and potential microRNA silencing of FZD8 in breast cancer

Breast cancer (BC) is one of the most widespread types affecting females, and therefore, early diagnosis critical. BC a complex heterogeneous disease affected by several key pathways. Among these, WNT proteins their frizzled receptors (FZD) have been demonstrated to be crucial in regulating number cellular molecular events tumorigenesis. The role receptor, FZD8, has received minimal attention; for that reason, present study examined prognostic value its protein expression pattern cohort. FZD8 cytoplasmic analysis revealed ~38% primary samples presented with high profile, whereas ~63% had low profile. Overall, ~46% malignant tissues lymph node‑positive exhibited an increased expression, 54% levels. An was associated clinicopathological characteristics patients, including survival rate, tumor vascular invasion, size grade, subtypes. Affymetrix microarray triple‑negative datasets were analyzed compared healthy breast order predict potential interfering microRNAs (miRNAs) WNT/FZD8 signaling pathway. A total 29 miRNAs interact pathway identified, eight which significant prediction score. target genes each predicted miRNA identified. On whole, findings suggest marker BC, shedding some light onto silencing mechanisms involved signaling.